TY - JOUR T1 - Comparing two regimens of in travaginal misoprostol with intravaginal gemeprost for second-trimesterpregnancy termination: a randomised controlled trial JF - Journal of Family Planning and Reproductive Health Care JO - J Fam Plann Reprod Health Care DO - 10.1136/jfprhc-2016-101652 SP - jfprhc-2016-101652 AU - Daniel Seow Choon Koh AU - Esther Pei Jing Ang AU - Jurja Chua Coyuco AU - Hua Zhen Teo AU - Xiaoling Huang AU - Xing Wei AU - Mor Jack Ng AU - Serene Liqing Lim AU - Kok Hian Tan Y1 - 2017/04/21 UR - http://jfprhc.bmj.com/content/early/2017/04/21/jfprhc-2016-101652.abstract N2 - Aim To compare the efficacy and safety of intravaginal misoprostol 200 µg, 400 µg and gemeprost regimens for second-trimester termination of pregnancy (TOP).Methods A three-armed randomised controlled trial (Clinical Trial Certificate 1100015) where 116 women undergoing second-trimester TOP were given intravaginal misoprostol 200 µg (n=37), misoprostol 400 µg (n=40) or gemeprost 1 mg (n=39) at 4-hour intervals until abortion occurred with a maximum of five doses.Results The misoprostol 400 µg group had the highest incidence of successful abortions (92.5%) compared to the misoprostol 200 µg (70.3%; p=0.017) and gemeprost 1 mg (74.4%; p=0.037) within 48 hours. There was no significant difference in abortion rate between misoprostol 200 µg and gemeprost. The misoprostol 400 µg group had the highest incidence of fever (70.0%) compared to misoprostol 200 µg (24.3%; p<0.001) and gemeprost 1 mg (46.2%; p=0.041). The gemeprost group had the highest incidence of diarrhoea (38.5%) compared to misoprostol 400 µg (10.0%; p=0.004) and misoprostol 200 µg (8.1%; p=0.003) groups.Conclusions Intravaginal misoprostol 400 µg at 4-hour intervals was the most effective regimen but was associated with a high incidence of fever. Misoprostol 200 µg demonstrated similar effectiveness as gemeprost and had lower incidence of diarrhoea. Gemeprost should not be first line for medical therapy given the cost, storage requirements and lower efficacy. ER -