Regimen | 5th percentile | Median | 95th percentile | Geometric mean | Geometric coefficient of variation (%) |
---|---|---|---|---|---|
EE AUC0–24 h, ss (pg*hour/ml) | |||||
FlexibleMIB | 517 | 811 | 1477 | 823 | 31.8 |
Conventional | 507 | 818 | 1519 | 841 | 32.6 |
Fixed extended | 485 | 782 | 1264 | 796 | 31.3 |
Total | 506 | 808 | 1434 | 822 | 31.9 |
DRSP AUC0–24 h, ss (ng*hour/ml) | |||||
FlexibleMIB | 582 | 879 | 1368 | 885 | 27.2 |
Conventional | 569 | 876 | 1353 | 873 | 31.3 |
Fixed extended | 553 | 862 | 1265 | 850 | 25.8 |
Total | 569 | 874 | 1345 | 876 | 27.9 |
DRSP, drospirenone; EE, ethinylestradiol; flexibleMIB, flexible extended regimen with management of intracyclic (breakthrough) bleeding.