Skip to main content

Advertisement

SpringerLink
Log in

Predicting Pregnancy in HIV-1-Discordant Couples

  • Report
  • Published:
AIDS and Behavior Aims and scope Submit manuscript

Abstract

This study examines the incidence and predictors of pregnancy in HIV-1-discordant couples from Nairobi, Kenya. Women from 454 discordant couples were followed for up to 2 years. One-year cumulative incidence of pregnancy was 9.7%. Pregnancy rates did not differ significantly between HIV-1-infected and uninfected women (HR = 1.46). The majority of pregnancies occurred among women < 30 years old reporting a desire for future children (1-year incidence 22.2%). Pregnancy rates may be high among discordant couples, indicating desire for children may override concerns of HIV-1 transmission and increase unprotected sex, and highlighting the need to make conception safer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Allen S, Meinzen-Derr J, Kautzman M, et al. Sexual behavior of HIV discordant couples after HIV counseling and testing. AIDS. 2003;17(5):733–40.

    Article  PubMed  Google Scholar 

  2. Myer L, Morroni C, Rebe K. Prevalence and determinants of fertility intentions of HIV-infected women and men receiving antiretroviral therapy in South Africa. AIDS Patient Care STDS. 2007;21(4):278–85.

    Article  PubMed  Google Scholar 

  3. Brubaker S, Bukusi EA, Odoyo J, Achando J, Okumu A, Cohen C. Pregnancy and HIV transmission among HIV discordant couples in a clinical trial in Kisumu, Kenya. 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Cape Town, South Africa; 2009 [abstract WELBC105].

  4. Gray RH, Li X, Kigozi G, et al. Increased risk of incident HIV during pregnancy in Rakai, Uganda: a prospective study. Lancet. 2005;366(9492):1182–8.

    Article  PubMed  Google Scholar 

  5. Moodley D, Esterhuizen TM, Pather T, Chetty V, Ngaleka L. High HIV incidence during pregnancy: compelling reason for repeat HIV testing. AIDS. 2009;23(10):1255–9.

    Article  PubMed  Google Scholar 

  6. Volmink J, Siegfried N, van der Merwe L, Brocklehurst P. Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection. Cochrane Database Syst Rev. 2007;(1):CD003510. doi:10.1002/14651858.CD003510.pub2.

  7. Bujan L, Hollander L, Coudert M, et al. Safety and efficacy of sperm washing in HIV-1-serodiscordant couples where the male is infected: results from the European CREAThE network. AIDS. 2007;21(14):1909–14.

    Article  PubMed  Google Scholar 

  8. Lingappa JR, Kahle E, Mugo N, Mujugira A, Magaret A, et al. Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study. PLoS ONE. 2009;4(4):e5272. doi:10.1371/journal.pone.0005272.

    Article  PubMed  Google Scholar 

  9. Guthrie BL, de Bruyn G, Farquhar C. HIV-1-discordant couples in sub-Saharan Africa: explanations and implications for high rates of discordancy. Curr HIV Res. 2007;5(4):416–29.

    Article  CAS  PubMed  Google Scholar 

  10. Bunnell R, Ekwaru JP, Solberg P, Wamai N, Bikaako-Kajura W, Were W, et al. Changes in sexual behavior and risk of HIV transmission after antiretroviral therapy and prevention interventions in rural Uganda. AIDS. 2006;20(1):85–92.

    Article  PubMed  Google Scholar 

  11. Homsy J, Bunnell R, Moore D, King R, Malamba S, et al. Reproductive intentions and outcomes among women on antiretroviral therapy in rural Uganda: a prospective cohort study. PLoS ONE. 2009;4(1):e4149. doi:10.1371/journal.pone.0004149.

    Article  PubMed  Google Scholar 

  12. Reid SE, Dai JY, Wang J, et al. Pregnancy, contraceptive use, and HIV acquisition in HPTN 039: relevance for HIV prevention trials among African women. J Acquir Immune Defic Syndr. 2010;53(5):606–13.

    PubMed  Google Scholar 

  13. Taulo F, Berry M, Tsui A, et al. Fertility intentions of HIV-1 infected and uninfected women in Malawi: a longitudinal study. AIDS Behav. 2009;13(Suppl 1):20–7.

    Article  PubMed  Google Scholar 

  14. US Census Bureau IPC, Global population profile. International database: age-specific fertility rates and selected derived measures. 2010.

  15. Matthews LT, Mukherjee JS. Strategies for harm reduction among HIV-affected couples who want to conceive. AIDS Behav. 2009;13(Suppl 1):5–11.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We thank the couples who participated in the study. Funding for this study was provided by the NIH/NIAID research grant R01 AI068431. Funding was also provided by the UW STD/AIDS training grant, grant T32 AI07140.

Author information

Authors and Affiliations

  1. Department of Epidemiology, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA

    Brandon L. Guthrie, Romel D. Mackelprang, Grace C. John-Stewart & Carey Farquhar

  2. Department of Medicine, University of Washington, Seattle, WA, USA

    Robert Y. Choi, Grace C. John-Stewart & Carey Farquhar

  3. Department of Global Health, University of Washington, Seattle, WA, USA

    Grace C. John-Stewart

  4. Centre for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya

    Rose Bosire

  5. Department of Obstetrics and Gynaecology, University of Nairobi, Nairobi, Kenya

    James N. Kiarie

  6. Department of Community Health, University of Nairobi, Nairobi, Kenya

    Anne Gatuguta

Authors
  1. Brandon L. Guthrie
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert Y. Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rose Bosire
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. James N. Kiarie
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Romel D. Mackelprang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Anne Gatuguta
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Grace C. John-Stewart
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Carey Farquhar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brandon L. Guthrie.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Guthrie, B.L., Choi, R.Y., Bosire, R. et al. Predicting Pregnancy in HIV-1-Discordant Couples. AIDS Behav 14, 1066–1071 (2010). https://doi.org/10.1007/s10461-010-9716-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10461-010-9716-x

Keywords

Search

Navigation