Original ArticleComparison of the Analgesic Effects of Oral Tramadol and Naproxen Sodium on Pain Relief During IUD Insertion
Section snippets
Materials and Methods
After approval from the local ethics and research committees, written informed consent was obtained from 103 healthy (physical status ASA I) multiparous women of childbearing age (18–49 years) who had been scheduled for IUD insertion. The study was randomized, controlled, and double blinded. Exclusion criteria were known allergy or hypersensitivity to NSAIDs or tramadol hydrochloride; current use of any narcotic or NSAID; history of epilepsy, peptic ulcer disease, bleeding disorder, asthma, or
Results
One hundred three patients were included in the study, 34 in group N, 34 in group C, and 35 in group T. The distribution of groups did not differ significantly from normality (Lilliefors test, p >.05). No significant between-group differences were observed in patient characteristics (Table 1). The IUDs were inserted in a standard manner by the same physician. The VAS scores were significantly different between the 3 groups (F (2, 100) = 101; p = .001) (Fig. 1). Variances were homogeneous
Discussion
In this randomized double-blinded study, orally administered tramadol and naproxen sodium were compared with placebo. Tramadol, 50 mg, demonstrated significantly superior analgesic effects over naproxen sodium, 550 mg, and placebo during the IUD insertion procedure. The mean pain score in the naproxen group was significantly lower than in the placebo group. Thus, we concluded that tramadol efficacy was better for pain control.
NSAIDs reduce pain and inflammation by blocking cyclooxygenase enzyme
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The authors have no commercial, proprietary, or financial interest in the products or companies described in this article.