Nanotechnology is expected to have an impact on all industries including semiconductors,
manufacturing, and biotechnology. Tools that provide the capability to characterize and …

Foot and mouth disease (FMD) in adult sheep and goats is frequently mild or unapparent,
but can cause high mortality in young animals. The recent outbreak of FMD in the United …

Idiopathic Pulmonary Fibrosis (IPF) now has two licensed treatments available. Pirfenidone
was the first drug to be licensed and approved for use, followed by nintedanib. We set out …

First-generation EGFR tyrosine kinase inhibitors (EGFR TKI) provide significant clinical
benefit in patients with advanced EGFR-mutant (EGFRm+) non–small cell lung cancer …

Plant disease epidemics continue to impact a world increasingly concerned with the quantity
and quality of food supply. This useful reference and textbook provides a detailed exposition …

Abstract ZD6474 [N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)
methoxy] quinazolin-4-amine] is a potent, po active, low molecular weight inhibitor of kinase …

The mammalian target of rapamycin (mTOR) kinase forms two multiprotein complexes,
mTORC1 and mTORC2, which regulate cell growth, cell survival, and autophagy. Allosteric …

Background An earlier analysis of this phase 3 trial showed that the addition of a cyclin-
dependent kinase 4 and 6 (CDK4/6) inhibitor to endocrine therapy provided a greater …

Huntington's disease (HD) pathology is well understood at a histological level but a
comprehensive molecular analysis of the effect of the disease in the human brain has not …

Background In MONALEESA-2, ribociclib plus letrozole showed improved progression-free
survival compared with letrozole alone as first-line treatment for postmenopausal patients …