[HTML][HTML] Protective role for antioxidants in acute kidney disease

JM Dennis, PK Witting - Nutrients, 2017 - mdpi.com
Acute kidney injury causes significant morbidity and mortality in the community and clinic.
Various pathologies, including renal and cardiovascular disease, traumatic …

Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease

B Chami, NJJ Martin, JM Dennis, PK Witting - Archives of biochemistry and …, 2018 - Elsevier
Inflammatory bowel disease (IBD) is a debilitating disorder involving inflammation of the
gastrointestinal tract. The incidence of IBD is increasing worldwide. Immunological …

Actions of “antioxidants” in the protection against atherosclerosis

ME Lönn, JM Dennis, R Stocker - Free radical biology and medicine, 2012 - Elsevier
This review addresses the role of oxidative processes in atherosclerosis and its resulting
cardiovascular disease by focusing on the outcome of antioxidant interventions. Although …

Autogenous regulation of transcription termination factor Rho and the requirement for Nus factors in Bacillus subtilis

CJ Ingham, J Dennis, PA Furneaux - Molecular microbiology, 1999 - Wiley Online Library
The expression and activity of transcription termination factor Rho and the requirement for
transcription elongation factors NusA and NusG was investigated in Bacillus subtilis. Rho …

[HTML][HTML] Evidence for oxidative pathways in the pathogenesis of PD: are antioxidants candidate drugs to ameliorate disease progression?

A Leathem, T Ortiz-Cerda, JM Dennis… - International journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder that arises due to a
complex and variable interplay between elements including age, genetic, and …

Neutrophil-mediated cardiac damage after acute myocardial infarction: significance of defining a new target cell type for developing cardioprotective drugs

M El Kazzi, BS Rayner, B Chami… - Antioxidants & redox …, 2020 - liebertpub.com
Significance: Acute myocardial infarction (AMI) is a leading cause of death worldwide. Post-
AMI survival rates have increased with the introduction of angioplasty as a primary coronary …

[HTML][HTML] The nitroxide 4-methoxy-tempo inhibits the pathogenesis of dextran sodium sulfate-stimulated experimental colitis

B Chami, PT San Gabriel, S Kum-Jew, XS Wang… - Redox Biology, 2020 - Elsevier
Inflammatory bowel disease (IBD) is a chronic condition characterised by leukocyte
recruitment to the gut mucosa. Leukocyte myeloperoxidase (MPO) produces the two …

Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y

SJM Escobar, GM Fong, SMB Winnischofer… - Chemico-Biological …, 2019 - Elsevier
Neuroblastoma is a common childhood cancer with high mortality. We evaluated the
capacity of the flavonoid, isoliquiritigenin (4, 2', 4'-trihydroxychalcone; ISL) to inhibit cellular …

[HTML][HTML] Serum amyloid A receptor blockade and incorporation into high-density lipoprotein modulates its pro-inflammatory and pro-thrombotic activities on vascular …

B Chami, N Barrie, X Cai, X Wang, M Paul… - International journal of …, 2015 - mdpi.com
The acute phase protein serum amyloid A (SAA), a marker of inflammation, induces
expression of pro-inflammatory and pro-thrombotic mediators including ICAM-1, VCAM-1, IL …

[HTML][HTML] High-density lipoprotein (HDL) inhibits serum amyloid A (SAA)-induced vascular and renal dysfunctions in apolipoprotein E-deficient mice

X Cai, G Ahmad, F Hossain, Y Liu, XS Wang… - International journal of …, 2020 - mdpi.com
Serum amyloid A (SAA) promotes endothelial inflammation and dysfunction that is
associated with cardiovascular disease and renal pathologies. SAA is an apoprotein for high …