Preclinical comparison of osimertinib with other EGFR-TKIs in EGFR-mutant NSCLC brain metastases models, and early evidence of clinical brain metastases activity
Purpose: Approximately one-third of patients with non–small cell lung cancer (NSCLC)
harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations (EGFRm) …
harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations (EGFRm) …
Response of the Nile and its catchment to millennial-scale climatic change since the LGM from Sr isotopes and major elements of East Mediterranean sediments
Changes in 87Sr/86Sr and major element geochemistry, from two sediment cores (9509 and
9501) in the Eastern Mediterranean (EM), were used to resolve changes in sediment …
9501) in the Eastern Mediterranean (EM), were used to resolve changes in sediment …
Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor
MRV Finlay, M Anderton, S Ashton, P Ballard… - 2014 - ACS Publications
Epidermal growth factor receptor (EGFR) inhibitors have been used clinically in the
treatment of non-small-cell lung cancer (NSCLC) patients harboring sensitizing (or …
treatment of non-small-cell lung cancer (NSCLC) patients harboring sensitizing (or …
Structure-and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR)
RA Ward, MJ Anderton, S Ashton… - Journal of medicinal …, 2013 - ACS Publications
A novel series of small-molecule inhibitors has been developed to target the double mutant
form of the epidermal growth factor receptor (EGFR) tyrosine kinase, which is resistant to …
form of the epidermal growth factor receptor (EGFR) tyrosine kinase, which is resistant to …
Late Glacial to Holocene benthic foraminifera in the Marmara Sea: implications for Black Sea–Mediterranean Sea connections following the last deglaciation
Benthic foraminifera were studied from four gravity cores that penetrated Holocene marine
sediments in the Marmara Sea. Morphogroup and assemblage analyses reveal that the …
sediments in the Marmara Sea. Morphogroup and assemblage analyses reveal that the …
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
W McCoull, RD Abrams, E Anderson… - Journal of Medicinal …, 2017 - ACS Publications
Inhibition of the protein–protein interaction between B-cell lymphoma 6 (BCL6) and
corepressors has been implicated as a therapeutic target in diffuse large B-cell lymphoma …
corepressors has been implicated as a therapeutic target in diffuse large B-cell lymphoma …
The experiences of adults with learning disabilities attending a sexuality and relationship group:“I want to get married and have kids”
M Box, J Shawe - Journal of Family Planning and Reproductive Health …, 2014 - srh.bmj.com
Background People with learning disabilities are frequently denied or restricted in their right
to express their sexuality by restrictive policies, negative attitudes or lack of awareness of …
to express their sexuality by restrictive policies, negative attitudes or lack of awareness of …
Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity
W McCoull, EJ Hennessy, K Blades, MR Box… - …, 2014 - pubs.rsc.org
A novel series of PAK1 inhibitors was discovered from a kinase directed screen. SAR
exploration in the selectivity pocket and solvent tail regions was conducted to understand …
exploration in the selectivity pocket and solvent tail regions was conducted to understand …
Plant genes influence microbial hubs that shape beneficial leaf communities
Although the complex interactions between hosts and microbial associates are increasingly
well documented, we still know little about how and why hosts shape microbial communities …
well documented, we still know little about how and why hosts shape microbial communities …
Acyl Polysilanes: New Acyl Anion Equivalents for Additions to Electron-Deficient Alkenes
J Bower, MR Box, M Czyzewski, AE Goeta… - Organic …, 2009 - ACS Publications
Silenes, generated through thermolysis of acylpolysilanes, add to α, β-unsaturated esters to
form cyclobutanes and silylsubstituted cyclopropanes in moderate yields. Upon Si− C bond …
form cyclobutanes and silylsubstituted cyclopropanes in moderate yields. Upon Si− C bond …