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A pre-coital pill? A preliminary in vitro study
  1. Gabor T Kovacs, MD, FRCOG, FRACOG, CREI, Reproductive Gynaecologist,
  2. Jacqui Hendricks, BSc Hons, Research Student,
  3. Deborah Summerbell, SRN, SRM, Nurse Practitioner and
  4. H W Gordon Baker, MD, PhD, FRACP, Andrologist
  1. Monash Medical School, Box Hill Hospital, Victoria, Australia
  1. Correspondence Professor Gabor T Kovacs, Monash Medical School, Box Hill Hospital, Nelson Road, Victoria 3128, Australia


The use of the progestogen-only pill as a ‘pre-coital contraceptive’ was tested by in vitro studies of sperm-mucus interaction. The results suggest that a single tablet of levonorgestrel 30 μg, or norethisterone 350 μg, was effective in preventing sperm migration in the cervical mucus about 12 hours later. This suggests that the progestogen-only pill may be effective as a ‘morning before pill’.

  • emergency contraception
  • mini-pill
  • progestogen-only contraception

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