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Premature ovarian failure
  1. Kate Maclaran and
  2. Nick Panay
  1. West London Menopause and PMS Centre, Queen Charlotte's & Chelsea and Chelsea and Westminster Hospitals, London, UK
  1. Correspondence to Mr Nick Panay, Department of Gynaecology, Queen Charlotte's & Chelsea Hospital, Du Cane Road, London W12 0HS, UK; nickpanay{at}


Premature ovarian failure (POF) is the occurrence of amenorrhoea, elevated gonadotrophins and hypoestrogenism in women under 40 years of age. It has important physical and psychological consequences and is increasingly common due to improved survival following treatment for malignancy. Despite this, it remains a poorly understood condition. Here we review the presentation and investigation of POF, discuss recent advances in the management of affected women, and suggest how our knowledge of the condition could be improved.

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  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.

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