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Journal Reviews
Prevention of HIV-1 infection with early antiretroviral therapy
  1. Michael Rayment
  1. Specialist Registrar in Genitourinary Medicine and HIV, St Stephen's Centre, Chelsea and Westminster Hospital, London, UK

https://doi.org/10.1136/jfprhc-2012-100379

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    MS Cohen, YQ Chen, M McCauley N Engl J Med 2011 365:493–505.

    The exciting evidence generated by this paper – that antiretroviral treatment of HIV-1 infection definitively reduces the risk of onward transmission of the virus by 96% – was rightly dubbed Science magazine's ‘Breakthrough of the Year’ in 2011.1 ,2

    It has long been known that the probability of sexual transmission of HIV is strongly correlated with concentrations of HIV in blood and genital fluids.3 ,4 Effective antiretroviral therapy (ART) produces prolonged and sustained suppression of HIV replication in these compartments, reducing the amount of free virus.5 ,6 Thus, there has long been a …

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    Footnotes

    • Competing interests Competing interests None.

    • Provenance and peer review Commissioned; internally peer reviewed.