Footnotes

• Competing interests Dr Mansour declares no support from any organisation for the submitted work. Dr Mansour has received research grants and honoraria for attending advisory board meetings, developing and delivering educational presentations from Aspen, Astellas, Bayer plc, Consilient Healthcare, HRA Pharma, Mithra, MSD and Vifor Pharma. No other relationships or activities have influenced the submitted work.

• Provenance and peer review Not commissioned; externally peer reviewed.