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Supplemental zinc and folic acid—no effect on pregnancy rate or semen quality

There have been mixed reports of the effect of supplemental zinc and folic acid consumption on the quality of semen, as both are essential for spermatogenesis. A 2017 meta-analysis concluded that large-scale prospective trials were needed. This multicentre, double-blind, placebo-controlled randomised trial enrolled more than 2000 couples seeking fertility treatment and evaluated live birth rate and a variety of semen analysis parameters. There was no difference in live birth rate or semen parameters between study groups. Supplementation with zinc and folic acid cannot be recommended for those undergoing fertility treatment.

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Telehealth interventions can improve obstetric outcomes and deliver contraception and medical abortion services

The coronavirus outbreak has necessitated many services moving partially or wholly to telemedicine models of delivery. Clinicians may be concerned about the evidence for safety and efficacy underpinning some of these changes. This systematic review of telehealth interventions in obstetrics and gynaecology has found that telemedicine is as effective and safe as face-to-face care for the provision of medical abortion. Likewise, it presents the evidence for sustained (and possibly improved) oral contraceptive use when provided through telehealth.

Obstet Gynecol 2020;135:371–82.

Long-acting injectable antiretroviral combination is non-inferior to oral treatment for suppression of HIV-1

Development of long-acting antiretrovirals …

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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research.

  • Provenance and peer review Commissioned; internally peer reviewed.