Article Text

Download PDFPDF
Highlights from the literature

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Maternal antidepressant use during pregnancy does not appear to cause neurodevelopmental disorders in children

Patients and clinicians may be worried about the effect of drugs consumed during pregnancy on the fetus, some of which may not manifest until later in life. Antidepressant medications are commonly used and, in some studies, have been associated with neurodevelopmental disorders. This large cohort study collected data on over 3 million pregnancies and had a 14 year follow-up period. In crude unadjusted analyses, there appeared to be a doubling of rates of neurodevelopmental disorders; however, after adjustment for confounding factors, these increases disappeared. Antidepressant use itself does not appear to be a direct cause of neurodevelopmental disorders but may indicate patients at higher need of screening and support.

JAMA Intern Med

Linzagolix with or without hormonal add-back therapy reduces menstrual blood loss for those with uterine fibroids

Uterine fibroids are an important cause of heavy menstrual bleeding. The non-surgical treatment options are relatively limited. These paired phase 3 studies compared linzagolix (an oral gonadotrophin-releasing hormone receptor antagonist) at two different doses with and without hormonal add-back versus placebo (five equally weighted study arms). All active arms had a reduction …

View Full Text


  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests JJR-W has received an educational grant from Gedeon Richter.

  • Provenance and peer review Commissioned; internally peer reviewed.