Maternal antidepressant use during pregnancy does not appear to cause neurodevelopmental disorders in children

Patients and clinicians may be worried about the effect of drugs consumed during pregnancy on the fetus, some of which may not manifest until later in life. Antidepressant medications are commonly used and, in some studies, have been associated with neurodevelopmental disorders. This large cohort study collected data on over 3 million pregnancies and had a 14 year follow-up period. In crude unadjusted analyses, there appeared to be a doubling of rates of neurodevelopmental disorders; however, after adjustment for confounding factors, these increases disappeared. Antidepressant use itself does not appear to be a direct cause of neurodevelopmental disorders but may indicate patients at higher need of screening and support.

JAMA Intern Med https://doi.org/10.1001/jamainternmed.2022.4268

Linzagolix with or without hormonal add-back therapy reduces menstrual blood loss for those with uterine fibroids

Uterine fibroids are an important cause of heavy menstrual bleeding. The non-surgical treatment options are relatively limited. These paired phase 3 studies compared linzagolix (an oral gonadotrophin-releasing hormone receptor antagonist) at two different doses with and without hormonal add-back versus placebo (five equally weighted study arms). All active arms had a reduction …