RT Journal Article
SR Electronic
T1 Ovulation induction with clomifene: a primary care perspective
JF Journal of Family Planning and Reproductive Health Care
JO J Fam Plann Reprod Health Care
FD British Medical Journal Publishing Group
SP 48
OP 52
DO 10.1136/jfprhc-2011-0103
VO 38
IS 1
A1 Scott Wilkes
A1 Alison Murdoch
YR 2012
UL http://jfprhc.bmj.com/content/38/1/48.abstract
AB Infertility affects one in seven couples during their lifetime. Approximately one-quarter of these will have an ovulatory disorder contributing to their inability to conceive. Ovulatory disorders represent the simplest form of infertility to treat, and where this is not a result of ovarian failure or poor ovarian reserve most women require ovulation induction with clomifene citrate (CC). This review aims to examine the role of CC in a general practice setting. CC is a simple, relatively safe, easily administered and well-tolerated efficacious drug. There is, however, a 10% risk of multiple births associated with its use. CC has been used in general practice for many years and continues to be used. Currently, guidelines do not describe its use in the general practice setting and the evidence for monitoring its use with mid-luteal progesterone estimation or ultrasound scanning is conflicting.