RT Journal Article
SR Electronic
T1 Does hormone replacement therapy (HRT) cause breast cancer? An application of causal principles to three studies
JF Journal of Family Planning and Reproductive Health Care
JO J Fam Plann Reprod Health Care
FD British Medical Journal Publishing Group
SP 80
OP 88
DO 10.1136/jfprhc-2012-100508
VO 39
IS 2
A1 Samuel Shapiro
A1 Richard D T Farmer
A1 John C Stevenson
A1 Henry G Burger
A1 Alfred O Mueck
A1 Anne Gompel
YR 2013
UL http://jfprhc.bmj.com/content/39/2/80.abstract
AB Background Based principally on findings in three studies, the Collaborative Reanalysis (CR), the Women's Health Initiative (WHI), and the Million Women Study, it is claimed that hormone replacement therapy (HRT) is an established cause of breast cancer. The authors have previously reviewed those studies (Parts 1–4). The WHI findings were first published in 2002, following which the use of HRT rapidly declined. A correspondingly rapid decline in the incidence of breast cancer has been reported, and attributed to the drop in the use of HRT. The evidence, however, is conflicting. Methods Using generally accepted causal criteria, in this article (Part 5) the authors evaluate reported trends in the incidence of breast cancer. Results The evidence to suggest a correlated decline in the incidence of breast cancer following a decline in the use of HRT has not adequately satisfied the criteria of time order, detection bias, confounding, statistical stability and strength of association, internal consistency, and external consistency; biological plausibility is difficult to assess. Conclusions Based on the observed trends in the incidence of breast cancer following the decline in HRT use, the ecological evidence is too limited either to support or refute the possibility that HRT causes breast cancer.