RT Journal Article SR Electronic T1 Assessing safety in hormonal male contraception: a critical appraisal of adverse events reported in a male contraceptive trial JF BMJ Sexual & Reproductive Health JO BMJ Sex Reprod Health FD British Medical Journal Publishing Group SP 139 OP 146 DO 10.1136/bmjsrh-2018-200206 VO 46 IS 2 A1 Carmen Abbe A1 Alison C Roxby YR 2020 UL http://jfprhc.bmj.com/content/46/2/139.abstract AB Introduction There is unmet need for male contraceptive options, but a recent injectable combination male contraceptive trial was terminated early due to adverse events (AEs).Methods We examined the frequency of reported AEs by male research participants compared with AEs reported in prescribing information of approved female hormonal contraceptive methods. Published data from trials of the top five most-used female hormonal contraceptives, supplemented by contemporary contraceptive research, were compared with the frequency of AEs reported in a male injectable hormonal contraceptive trial.Results We observed similar frequencies of AEs reported by users of male contraceptives compared with those reported by female users. Among quantitatively comparable AEs, compared with men, women reported experiencing higher frequencies of headaches, pelvic pain, and weight gain and similar frequencies of decreased libido. Compared with women, men reported experiencing higher frequencies of acne and mood changes. Men discontinued participation due to AEs at a lower frequency than women.Conclusions Female hormonal methods generally have similar frequencies of AEs to those reported in a recent male hormonal contraceptive trial, and male users had lower rates of discontinuation due to AEs. There were fewer serious AEs of the male contraceptive than reported in contemporary female trials which resulted in FDA licensure. This suggests there may be implicit bias in the scientific community regarding the level of acceptable risk for users of male contraceptive methods.