Interacting factor | COC | CTP | POP desogestrel | POP conventional | Implant | POI | IUS |
Affected by reduced mobility | May increase VTE risk | May increase VTE risk | No | No | No | May increase osteoporosis risk | Technicalities of insertion |
Affected by body mass index | If raised may increase VTE risk | If raised may increase VTE risk | No | No | No | If low may increase osteoporosis risk | Technicalities of insertion |
Enzyme-inducing medication | May affect | May affect | May affect | May affect | May affect | No effect | No effect |
Likelihood of amenorrhoea | Variable/Increased if tailored regimen | Variable/Increased if tailored regimen | Moderate/ low | Low | Moderate | Good | Good |
COC, combined oral contraceptive; CTP, combined transdermal patch; IUS, intrauterine system; POI, progestogen-only injectable; POP, progestogen-only pill; VTE, venous thromboembolism.