Table 4

Serious adverse events reported by FDA-approved prescribing information of contemporary hormonal female contraceptives and those assessed to be possibly or probably related to the male injectable contraceptive.*

Publication
ContraceptiveReported serious AEs
COCDepression, pulmonary embolism, toxic skin eruption, uterine leiomyomaYasmin12
COCMigraine, cervical dysplasiaYaz13
COCCarcinoma of the cervix in situ, cervical dysplasiaOrtho Tri-Cyclen Lo11
COCBreast cancer, carcinoma of the cervix in situ,
hypertension, migraine
Ortho Tri-Cyclen14
IUSGroup A streptococcal sepsisMirena15
Vaginal ringDeep vein thrombosis, anxiety, cholelithiasis, vomitingNuvaRing17
Male injectable combination contraceptiveDepression, intentional paracetamol overdose, tachycardia with paroxysmal atrial fibrillationBehre et al 20168
  • *The number of female participants that reported each adverse event was not reported.

  • AE, adverse event; COC, combined oral contraceptive; FDA, Food and Drug Administration; IUS, intrauterine system.