Cycle 1: Baseline cycle | Cycle 2: Treatment cycle | ||||||||||||
Subject | Total cycle length (days) | LF >18 mm | Total cycle length (days) | LF >18 mm, day of medication | LF maximum diameter (mm) | Maximum ES thickness (mm) | *Luteal P level (ng/mL) | Ovulation dysfunction | |||||
Ovulation disruption | LH surge blunted | *Non-ovulatory luteal P | Met >1 ovulation dysfunction criteria | ||||||||||
Cycle day | LH level (IU/L) | Cycle Day | LH level (IU/L) | LF persist >5 days | |||||||||
01 | 27 | 10 | 8.7 | 31 | 10 | 7.2 | 24.2 | 21.6 | 1.3 | Yes | Yes | Yes | Yes |
02 | 32 | 12 | 4.4 | 32 | 13 | 18.5 | 22.9 | 11.5 | 5.7 | No | Yes | No | Yes |
04 | 29 | 11 | 13.6 | 29 | 10 | 6.2 | 25.7 | 9.30 | 6.6 | Yes | No | No | Yes |
05 | 34 | 17 | 34.8 | 37 | 16 | 14.6 | 21.0 | 12.1 | 1.5 | Yes | No | Yes | Yes |
06 | 26 | 10 | 13.9 | 28 | 10 | 7.8 | 23.1 | 12.8 | 5.3 | No | No | No | No |
07 | 25 | 9 | 5.4 | 34 | 11 | 5.7 | 21.8 | 12.7 | 4 | Yes | Yes | No | Yes |
09 | 24 | 9 | 9.7 | 27 | 11 | 7.9 | 23.9 | 9.6 | 8.8 | Yes | Yes | No | Yes |
10 | 32 | 14 | 9.8 | 36 | 17 | 10.9 | 18.9 | 12.3 | 3 | Yes | No | No | Yes |
12 | 28 | 10 | 55.2 | 31 | 10 | 6.80 | 17.4 | 11.6 | 5.4 | No | Yes | No | Yes |
Mean | 28.6 | 11 | 17.3 | 31.9 | 12 | 9.5 | 22.1 | 12.6 | 4.6 | ||||
SD | 3.5 | 2.7 | 16.8 | 4.0 | 2.7 | 4.4 | 2.6 | 3.6 | 2.4 | ||||
Median | 28.0 | 10.0 | 9.8 | 32.0 | 11.0 | 7.8 | 22.9 | 12.1 | 5.3 | ||||
Range | 24–34 | 9–17 | 4.4–55.2 | 27–37 | 10–17 | 5.7–18.5 | 17.4–25.7 | 9.3–21.6 | 1.3–8.8 |
Ovulation dysfunction criteria defined based on established definitions from prior studies.
*Ovulatory luteal phase progesterone level defined as >3.5
ES, endometrial stripe; LF, lead follicle; LH, luteinizing hormone; P, progesterone; SD, standard deviation.