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Perinatal characteristics and retinoblastoma

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Abstract

Purpose

The etiology of retinoblastoma remains poorly understood. In the present study, we examined associations between perinatal factors and retinoblastoma risk in California children.

Methods

We identified 609 retinoblastoma cases (420 unilateral, 187 bilateral, and 2 with laterality unknown) from California Cancer Registry records of diagnoses 1988–2007 among children < 6 years of age. We randomly selected 209,051 controls from California birth rolls. The source of most study data was birth certificates. Multivariable logistic regression was used to examine associations between retinoblastoma and perinatal characteristics.

Results

Bilateral retinoblastoma was associated with greater paternal age [for fathers over 35, crude odds ratio (OR) = 1.73, 95 % confidence interval (CI) 1.20, 2.47] and with twin births (OR = 1.93, 95 % CI 0.99, 3.79). Among unilateral cases, we observed an increased risk among children of US-born Hispanic mothers (OR = 1.34, 95 % CI 1.01, 1.77) while a decreased risk was observed for infants born to mothers with less than 9 years of education (OR = 0.70, 95 % CI 0.49, 1.00), a group that consisted primarily of mothers born in Mexico. We observed that maternal infection in pregnancy with any STD (OR = 3.59, 95 % CI 1.58, 8.15) was associated with bilateral retinoblastoma.

Conclusions

This study supports the findings of previous investigations reporting associations between parental age, HPV infection, and retinoblastoma.

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References

  1. Leiderman YI, Kiss S, Mukai S (2007) Molecular genetics of RB1–the retinoblastoma gene. Semin Ophthalmol 22:247–254

    Article  PubMed  Google Scholar 

  2. Abramson DH, Schefler AC (2004) Update on retinoblastoma. Retina 24:828–848

    Article  PubMed  Google Scholar 

  3. Stiller CA, Parkin DM (1996) Geographic and ethnic variations in the incidence of childhood cancer. Br Med Bull 52:682–703

    Article  PubMed  CAS  Google Scholar 

  4. Parkin DM, International Agency for Research on Cancer (1998) International incidence of childhood cancer, vol II. International Agency for Research on Cancer, Lyon

    Google Scholar 

  5. Bunin GR, Meadows AT, Emanuel BS, Buckley JD, Woods WG, Hammond GD (1989) Pre- and post-conception factors associated with sporadic heritable and nonheritable retinoblastoma. Cancer Res 49:5730–5735

    PubMed  CAS  Google Scholar 

  6. Johnson KJ, Carozza SE, Chow EJ et al (2009) Parental age and risk of childhood cancer: a pooled analysis. Epidemiology 20:475–483

    Article  PubMed  Google Scholar 

  7. Sivakumaran TA, Ghose S, Kumar HAS, Kucheria K (2000) Parental age in Indian patients with sporadic hereditary retinoblastoma. Ophthalmic Epidemiol 7:285–291

    Article  PubMed  CAS  Google Scholar 

  8. Yip BH, Pawitan Y, Czene K (2006) Parental age and risk of childhood cancers: a population-based cohort study from Sweden. Int J Epidemiol 35:1495–1503

    Article  PubMed  Google Scholar 

  9. DerKinderen DJ, Koten JW, Tan KE, Beemer FA, Van Romunde LK, Den Otter W (1990) Parental age in sporadic hereditary retinoblastoma. Am J Ophthalmol 110:605–609

    PubMed  CAS  Google Scholar 

  10. Anand B, Ramesh C, Appaji L et al (2011) Prevalence of high-risk human papillomavirus genotypes in retinoblastoma. Br J Ophthal 95:1014–1018

    Article  Google Scholar 

  11. Montoya-Fuentes H, de la Paz Ramirez-Munoz M, Villar-Calvo V et al (2003) Identification of DNA sequences and viral proteins of 6 human papillomavirus types in retinoblastoma tissue. Anticancer Res 23:2853–2862

    PubMed  CAS  Google Scholar 

  12. Palazzi MA, Yunes JA, Cardinalli IA et al (2003) Detection of oncogenic human papillomavirus in sporadic retinoblastoma. Acta Ophthalmol Scand 81:396–398

    Article  PubMed  CAS  Google Scholar 

  13. Orjuela M, Castaneda VP, Ridaura C et al (2000) Presence of human papilloma virus in tumor tissue from children with retinoblastoma: an alternative mechanism for tumor development. Clin Cancer Res 6:4010–4016

    PubMed  CAS  Google Scholar 

  14. Antoneli CB, Ribeiro KB, Sredni ST et al (2011) Low prevalence of HPV in Brazilian children with retinoblastoma. J Med Virol 83:115–118

    Article  PubMed  Google Scholar 

  15. Mohan A, Venkatesan N, Kandalam M et al (2009) Detection of human papillomavirus DNA in retinoblastoma samples: a preliminary study. J Pediatr Hematol Oncol 31:8–13

    Article  PubMed  CAS  Google Scholar 

  16. Shetty OA, Naresh KN, Banavali SD et al (2012) Evidence for the presence of high risk human papillomavirus in retinoblastoma tissue from nonfamilial retinoblastoma in developing countries. Pediatr Blood Cancer 2(58):185–190

    Article  Google Scholar 

  17. Hooper ML (1999) Is sunlight an aetiological agent in the genesis of retinoblastoma? Br J Cancer 79:1273–1276

    Article  PubMed  CAS  Google Scholar 

  18. Jemal A, Devesa SS, Fears TR, Fraumeni JF Jr (2000) Retinoblastoma incidence and sunlight exposure. Br J Cancer 82:1875–1878

    Article  PubMed  CAS  Google Scholar 

  19. Orjuela MA, Titievsky L, Liu X et al (2005) Fruit and vegetable intake during pregnancy and risk for development of sporadic retinoblastoma. Cancer Epidemiol Biomarkers Prev 14:1433–1440

    Article  PubMed  Google Scholar 

  20. Bunin GR, Petrakova A, Meadows AT et al (1990) Occupations of parents of children with retinoblastoma: a report from the Children’s Cancer Study Group. Cancer Res 50:7129–7133

    PubMed  CAS  Google Scholar 

  21. Mutanen P, Hemminki K (2001) Childhood cancer and parental occupation in the Swedish Family-Cancer Database. J Occup Environ Med 43:952–958

    Article  PubMed  CAS  Google Scholar 

  22. Olsen JH, de Nully Brown P, Schulgen G, Jensen OM (1991) Parental employment at time of conception and risk of cancer in offspring. Eur J Cancer 27:958–965

    Article  PubMed  CAS  Google Scholar 

  23. Moll AC, Imhof SM, Cruysberg JR, Schouten-van Meeteren AY, Boers M, van Leeuwen FE (2003) Incidence of retinoblastoma in children born after in vitro fertilisation. Lancet 361:309–310

    Article  PubMed  Google Scholar 

  24. Bradbury BD, Jick H (2004) In vitro fertilization and childhood retinoblastoma. Br J Clin Pharmacol 58:209–211

    Article  PubMed  Google Scholar 

  25. BenEzra D (2005) IVF and retinoblastoma. Br J Ophthalmol 89:393

    Article  PubMed  CAS  Google Scholar 

  26. Dommering CJ, van der Hout AH, Meijers-Heijboer H, Marees T, Moll AC (2012) IVF and retinoblastoma revisited. Fertil Steril 97:79–81

    Article  PubMed  Google Scholar 

  27. Heck JE, Lombardi CA, Cockburn M, Meyers TJ, Wilhelm M, Ritz B (2012) Epidemiology of rhabdoid tumors of early childhood. Pediatr Blood Cancer. doi:10.1002/pbc.24141

  28. Ritz B, Wilhelm M, Hoggatt KJ, Ghosh JK (2007) Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the University of California, Los Angeles. Am J Epidemiol 166:1045–1052

    Article  PubMed  Google Scholar 

  29. Yost K, Perkins C, Cohen R, Morris C, Wright W (2001) Socioeconomic status and breast cancer incidence in California for different race/ethnic groups. Canc Cause Contr 12:703–711

    Article  CAS  Google Scholar 

  30. Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M (1996) A United States national reference for fetal growth. Obstet Gynecol 87:163–168

    Article  PubMed  CAS  Google Scholar 

  31. CDC (1989) 1989 sexually transmitted disease treatment guidelines. MMWR Morb Mortal Wkly Rep 38 Suppl 8:1–43

  32. Naumova A, Sapienza C (1994) The genetics of retinoblastoma, revisited. Am J Hum Genet 54:264–273

    PubMed  CAS  Google Scholar 

  33. Curado MP, Edwards B, Shin HR et al (2007) Cancer incidence in five continents, vol IX. IARC, Lyon

    Google Scholar 

  34. Moll AC, Imhof SM, Kuik DJ et al (1996) High parental age is associated with sporadic hereditary retinoblastoma: the Dutch retinoblastoma register 1862–1994. Hum Genet 98:109–112

    Article  PubMed  CAS  Google Scholar 

  35. Matsunaga E, Minoda K, Sasaki MS (1990) Parental age and seasonal variation in the births of children with sporadic retinoblastoma: a mutation-epidemiologic study. Hum Genet 84:155–158

    Article  PubMed  CAS  Google Scholar 

  36. Zhu XP, Dunn JM, Phillips RA et al (1989) Preferential germline mutation of the paternal allele in retinoblastoma. Nature 340:312–313

    Article  PubMed  CAS  Google Scholar 

  37. Dryja TP, Morrow JF, Rapaport JM (1997) Quantification of the paternal allele bias for new germline mutations in the retinoblastoma gene. Hum Genet 100:446–449

    Article  PubMed  CAS  Google Scholar 

  38. de Camargo B, de Oliveira Ferreira JM, de Souza Reis R, Ferman S, de Oliveira Santos M, Pombo-de-Oliveira MS (2011) Socioeconomic status and the incidence of non-central nervous system childhood embryonic tumours in Brazil. BMC Cancer 11:160

    Article  PubMed  Google Scholar 

  39. Bunin GR, Felice MA, Davidson W et al (2011) Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation. Int J Cancer 128:2393–2404

    Article  PubMed  CAS  Google Scholar 

  40. Cervantes A, Keith L, Wyshak G (1999) Adverse birth outcomes among native-born and immigrant women: replicating national evidence regarding Mexicans at the local level. Matern Child Health J 3:99–109

    Article  PubMed  CAS  Google Scholar 

  41. Hessol NA, Fuentes-Afflick E (2000) The perinatal advantage of Mexican-origin Latina women. Ann Epidemiol 10:516–523

    Article  PubMed  CAS  Google Scholar 

  42. de la Rosa IA (2002) Perinatal outcomes among Mexican Americans: a review of an epidemiological paradox. Ethn Dis 12:480–487

    PubMed  Google Scholar 

  43. Harley K, Eskenazi B (2006) Time in the United States, social support and health behaviors during pregnancy among women of Mexican descent. Soc Sci Med 62:3048–3061

    Article  PubMed  Google Scholar 

  44. Batis C, Hernandez-Barrera L, Barquera S, Rivera JA, Popkin BM (2011) Food acculturation drives dietary differences among Mexicans, Mexican Americans, and Non-Hispanic Whites. J Nutr 141:1898–1906

    Article  PubMed  CAS  Google Scholar 

  45. Guendelman S, Thornton D, Gould J, Hosang N (2006) Mexican women in California: differentials in maternal morbidity between foreign and US-born populations. Paediatr Perinat Epidemiol 20:471–481

    Article  PubMed  Google Scholar 

  46. Acevedo-Garcia D, Soobader MJ, Berkman LF (2007) Low birthweight among US Hispanic/Latino subgroups: the effect of maternal foreign-born status and education. Soc Sci Med 65:2503–2516

    Article  PubMed  Google Scholar 

  47. Harley K, Stamm NL, Eskenazi B (2007) The effect of time in the US on the duration of breastfeeding in women of Mexican descent. Matern Child Health J 11:119–125

    Article  PubMed  Google Scholar 

  48. Hoggatt KJ, Flores M, Solorio R, Wilhelm M, Ritz B (2011) The “Latina Epidemiologic Paradox” revisited: the role of birthplace and acculturation in predicting infant low birthweight for Latinas in Los Angeles, CA. J Immigr Minor Health. doi:10.1007/s10903-011-9556-4

  49. Heck JE, Ritz B, Hung RJ, Hashibe M, Boffetta P (2009) The epidemiology of neuroblastoma: a review. Paediatr Perinat Epidemiol 23:125–143

    Article  PubMed  Google Scholar 

  50. IARC Monographs Program (2009) A review of human carcinogens: part E. Lancet Oncol 10:1033–1034

    Article  Google Scholar 

  51. Chu A, Heck JE, Ribeiro KB et al (2010) Wilms’ tumour: a systematic review of risk factors and meta-analysis. Paediatr Perinat Epidemiol 24:449–469

    Article  PubMed  Google Scholar 

  52. Schuz J, Forman MR (2007) Birthweight by gestational age and childhood cancer. Canc Cause Contr 18:655–663

    Article  Google Scholar 

  53. Leal-Leal C, Flores-Rojo M, Medina-Sanson A et al (2004) A multicentre report from the Mexican Retinoblastoma Group. Br J Ophthalmol 88:1074–1077

    Article  PubMed  CAS  Google Scholar 

  54. Ault KA (2006) Epidemiology and natural history of human papillomavirus infections in the female genital tract. Infect Dis Obstet Gynecol 2006(Suppl):40470

    PubMed  Google Scholar 

  55. Moscicki AB, Hills N, Shiboski S et al (2001) Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females. JAMA 285:2995–3002

    Article  PubMed  CAS  Google Scholar 

  56. Gillison ML, Chen R, Goshu E et al (2007) Human retinoblastoma is not caused by known pRb-inactivating human DNA tumor viruses. Int J Cancer 120:1482–1490

    Article  PubMed  CAS  Google Scholar 

  57. Durst M, Gissmann L, Ikenberg H, zur Hausen H (1983) A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA 80:3812–3815

    Article  PubMed  CAS  Google Scholar 

  58. Ribeiro KB, Levi JE, Pawlita M et al (2011) Low human papillomavirus prevalence in head and neck cancer: results from two large case-control studies in high-incidence regions. Int J Epidemiol 40:489–502

    Article  PubMed  Google Scholar 

  59. Schieve LA, Devine O, Boyle CA, Petrini JR, Warner L (2009) Estimation of the contribution of non-assisted reproductive technology ovulation stimulation fertility treatments to US singleton and multiple births. Am J Epidemiol 170:1396–1407

    Article  PubMed  Google Scholar 

  60. Duwe KN, Reefhuis J, Honein MA, Schieve LA, Rasmussen SA (2010) Epidemiology of fertility treatment use among US women with live born infants, 1997–2004. J Womens Health 19:407–416

    Article  Google Scholar 

  61. Hosler AS, Nayak SG, Radigan AM (2010) Agreement between self-report and birth certificate for gestational diabetes mellitus: New York State PRAMS. Matern Child Health J 14(5):786–789

    Google Scholar 

  62. Dobie SA, Baldwin LM, Rosenblatt RA, Fordyce MA, Andrilla CH, Hart LG (1998) How well do birth certificates describe the pregnancies they report? The Washington State experience with low-risk pregnancies. Matern Child Health J 2:145–154

    Article  PubMed  CAS  Google Scholar 

  63. Baumeister L, Marchi K, Pearl M, Williams R, Braveman P (2000) The validity of information on “race” and “Hispanic ethnicity” in California birth certificate data. Health Serv Res 35:869–883

    PubMed  CAS  Google Scholar 

  64. Northam S, Knapp TR (2006) The reliability and validity of birth certificates. J Obstet Gynecol Neonatal Nurs 35:3–12

    Article  PubMed  Google Scholar 

  65. Reichman NE, Hade EM (2001) Validation of birth certificate data. A study of women in New Jersey’s HealthStart program. Ann Epidemiol 11:186–193

    Article  PubMed  CAS  Google Scholar 

  66. Roohan PJ, Josberger RE, Acar J, Dabir P, Feder HM, Gagliano PJ (2003) Validation of birth certificate data in New York State. J Community Health 28:335–346

    Article  PubMed  Google Scholar 

  67. Zhang Z, Macaluso M, Cohen B et al (2010) Accuracy of assisted reproductive technology information on the Massachusetts birth certificate, 1997–2000. Fertil Steril 94:1657–1661

    Article  PubMed  Google Scholar 

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Acknowledgments

This study was supported by grants from the National Institute of Environmental Health Sciences (R21ES018960, R21ES019986). We would like to thank Dr. Janet Sinsheimer for her discussions of the manuscript.

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Correspondence to Julia E. Heck.

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Heck, J.E., Lombardi, C.A., Meyers, T.J. et al. Perinatal characteristics and retinoblastoma. Cancer Causes Control 23, 1567–1575 (2012). https://doi.org/10.1007/s10552-012-0034-7

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  • DOI: https://doi.org/10.1007/s10552-012-0034-7

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