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HIV-1 Prevention for HIV-1 Serodiscordant Couples

  • Antiretroviral Therapies (A Pozniak, Section Editor)
  • Published:
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Abstract

A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother-to-child transmission for HIV-1-infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.

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Acknowledgments

We thank Dr. Rachel Baggaley for her review and comments on the manuscript.

Funding: the Bill and Melinda Gates Foundation (47674) and the National Institutes of Health (R01 AI083034, R21 NR012663, and R01 MH095507).

Disclosure

K. Curran: none; J. M. Baeten: none; T. J. Coates: none; A. Kurth: none; N. R. Mugo: none; C. Celum: board membership for Merck.

Author information

Authors and Affiliations

  1. International Clinical Research Center, Department of Global Health, University of Washington, Box 359927, 325 Ninth Avenue, Seattle, WA, 98104, USA

    Kathryn Curran, Jared M. Baeten & Connie Celum

  2. Division of Infectious Diseases and Program in Global Health, David Geffen School of Medicine, University of California, 9911 West Pico Blvd., Suite 955, Los Angeles, CA, 90035-2703, USA

    Thomas J. Coates

  3. New York University College of Nursing, 1006 726 Broadway, New York, NY, 10003, USA

    Ann Kurth

  4. University of Nairobi Institute of Tropical and Infectious Diseases (UNITID), Kenyatta National Hospital, Ngong Rd, P.O. Box 19865-00202, Nairobi, Kenya

    Nelly R. Mugo

Authors
  1. Kathryn Curran
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  2. Jared M. Baeten
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  3. Thomas J. Coates
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  4. Ann Kurth
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  5. Nelly R. Mugo
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  6. Connie Celum
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Corresponding author

Correspondence to Connie Celum.

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Curran, K., Baeten, J.M., Coates, T.J. et al. HIV-1 Prevention for HIV-1 Serodiscordant Couples. Curr HIV/AIDS Rep 9, 160–170 (2012). https://doi.org/10.1007/s11904-012-0114-z

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  • DOI: https://doi.org/10.1007/s11904-012-0114-z

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