Elsevier

Fertility and Sterility

Volume 70, Issue 3, September 1998, Pages 492-499
Fertility and Sterility

In Vitro Fertilization
Adverse effects of hydrosalpinx on pregnancy rates after in vitro fertilization–embryo transfer

https://doi.org/10.1016/S0015-0282(98)00200-3Get rights and content
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Abstract

Objective: To determine the effect of hydrosalpinx on the establishment of pregnancy after IVF-ET.

Design: Metaanalysis.

Setting: University medical center.

Patient(s) and Intervention(s): All published reports (n = 13) and abstracts (n = 10) in English that examined the relation between hydrosalpinx and IVF-ET were included in the analysis. The metaanalysis was performed by first calculating the odds ratios for each trial and then combining them to obtain a pooled estimate of the odds ratio and a 95% confidence interval.

Main Outcome Measure(s): Clinical pregnancy.

Result(s): A total of 5,569 cycles was reviewed in the group without hydrosalpinx, and a total of 1,144 was reviewed in the group with hydrosalpinx. The clinical pregnancy rate was approximately 50% lower in patients who had hydrosalpinx. Similarly, the implantation rate was decreased by 50%. These effects were observed also in thawed ET cycles. The abortion rate was more than twofold higher in patients who had hydrosalpinx.

Conclusion(s): This metaanalysis suggests that hydrosalpinx is associated with a reduced chance of implantation and an increased risk of pregnancy loss.

Keywords

Hydrosalpinx
IVF-ET
pregnancy rate
implantation
pregnancy loss

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