Responses to hormones that act through nuclear receptors are controlled by modulating
hormone concentrations not only in the circulation but also within target tissues. The role of …

Objectives The steroid hormone vitamin D has roles in immunomodulation and bone health.
Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy …

Objective Endocrine systems are disrupted in acute illness, and symptoms reported
following coronavirus disease 2019 (COVID‐19) are similar to those found with clinical …

Objectives To study the incidence of, and risk factors for, iatrogenic hypoglycaemia following
GwI infusion in our institution. Context Hyperkalaemia is a life‐threatening biochemical …

Pharmacology Amitriptyline was the second tricyclic antidepressant to be synthesised by
Merck in 1960 after imipramine. Its main action is to increase activity of serotonergic and …

The article focuses on actions taken for improving the safety of steroid-dependent patients
by endocrine community in Great Britain. Topics discussed include emergency guideline …

Journal readers may be aware that population uptake of the National Health Service (NHS)
Cervical Screening Programme has been declining in recent years with up to one in four of …

Background: Hyperandrogenism in congenital adrenal hyperplasia (CAH) is associated with
virilisation in female patients and subfertility in both male and female patients. However, little …

Background: Pituitary carcinoma is a rare diagnosis, occurring in< 1% of pituitary tumours.
Most are hormonally active and resistant to conventional treatment. We present a rare case …

BMJ Open is committed to open peer review. As part of this commitment we make the peer
review history of every article we publis Page 1 BMJ Open is committed to open peer review …