Ten years ago, a consensus report on the optimization of tacrolimus was published in this
journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International …

The clinical management of tacrolimus, a macrolide used as immunosuppressant after
transplantation, is complicated by its narrow therapeutic index in combination with inter- and …

BACKGROUND Tacrolimus is a 23-membered ring compound with a molecular weight of
804 daltons (Fig. 1); it is a macrolide antibiotic that is highly lipophilic and poorly soluble in …

The hepatic cytochrome P-450 responsible for metabolism of the structurally related
macrolides FK506 and rapamycin in humans was identified using in vitro studies. FK506 and …

Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of
diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of …

The small intestinal metabolism of tacrolimus, which is used as an immunosuppressant in
transplantation medicine, was investigated in this study. Tacrolimus was metabolized in vitro …

Mycophenolate mofetil (MMF) is almost completely absorbed from the gut and is rapidly de-esterified
into its active drug, mycophenolic acid (MPA). The main metabolite is …

In an in vitro study, we compared the cytochrome P450 (CYP)-dependent metabolism and
drug interactions of the acid and lactone forms of the 3-hydroxy-3-methylglutaryl (HMG)-CoA …

Objective Our objective was to compare the intravenous and oral pharmacokinetics of
tacrolimus among subjects of three different ethnic backgrounds, African American, white, and …

3-Hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.88) inhibitors are the most
effective drugs to lower cholesterol in transplant patients. However, immunosuppressants and …